Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France
Cécile Souty
(1)
,
Ana-Maria Vilcu
(1)
,
Lisandru Capai
(1, 2)
,
Sylvie van Der Werf
(3, 4)
,
Martine Valette
(5)
,
Thierry Blanchon
(1)
,
Bruno Lina
(5, 6)
,
Sylvie Behillil
(3, 4)
,
Thomas Hanslik
(1, 7, 8)
,
Alessandra Falchi
(2)
1
iPLESP -
Institut Pierre Louis d'Epidémiologie et de Santé Publique
2 EA Bioscope Corse Méditerranée : Dynamique des infections virales en milieu insulaire
3 GMV-ARN (UMR_3569 / U-Pasteur_2) - Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses
4 CNR - Centre National de Référence des virus influenzae (Grippe)
5 Virpath - Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control [CIRI]
6 CNR des virus influenza - Laboratoire de Virologie [GH Nord HCL, Lyon]
7 Service de Médecine Interne
8 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
2 EA Bioscope Corse Méditerranée : Dynamique des infections virales en milieu insulaire
3 GMV-ARN (UMR_3569 / U-Pasteur_2) - Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses
4 CNR - Centre National de Référence des virus influenzae (Grippe)
5 Virpath - Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control [CIRI]
6 CNR des virus influenza - Laboratoire de Virologie [GH Nord HCL, Lyon]
7 Service de Médecine Interne
8 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
Sylvie van Der Werf
- Fonction : Auteur
- PersonId : 1202918
- IdHAL : sylvie-van-der-werf
- ORCID : 0000-0002-1148-4456
- IdRef : 070954534
Martine Valette
- Fonction : Auteur
- PersonId : 837412
Bruno Lina
- Fonction : Auteur
- PersonId : 837368
- ORCID : 0000-0002-8959-2123
- IdRef : 075685132
Sylvie Behillil
- Fonction : Auteur
- PersonId : 774966
- ORCID : 0000-0002-1520-5020
Alessandra Falchi
- Fonction : Auteur
- PersonId : 764922
- ORCID : 0000-0003-0799-1460
Résumé
Background: The ongoing 2016/17 influenza epidemic in France is characterized by the circulation of A(H3N2) viruses, known to cause more severe illness among at risk populations.Objectives: The purpose of our study was to provide early influenza vaccine effectiveness (IVE) estimates for the ongoing influenza epidemic in France and compare these estimates over the six post-pandemic IVE.Study design: We used clinical and virological data collected in primary care by the French Sentinelles network. IVE in preventing influenza infection was estimated by the test-negative design method. The screening method was used to estimate IVE in preventing medically-attended influenza-like illness among target groups (<65 year with chronic diseases and ≥65 years) since 2010/11 influenza epidemic.Results: Early IVE estimates in primary care against influenza A(H3N2) were 48% (95% confidence interval (CI): 22 to 66) overall and 39% (95% CI: -17 to 69) among elderly (aged 65 and older). In comparison to the last six epidemics, 2016/17 early IVE in preventing influenza-like illness among target groups showed VE estimates higher to those reported during the 2011/12 and 2014/15 epidemics.Conclusions: The moderate 2016/17 IVE estimates were higher than those estimated during influenza A(H3N2) epidemics with vaccine mismatch.
Domaines
Sciences du Vivant [q-bio]Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Early estimates of 2016/17 seasonal influenza vaccine effectiveness in primary care in France
|
Résumé |
en
Background: The ongoing 2016/17 influenza epidemic in France is characterized by the circulation of A(H3N2) viruses, known to cause more severe illness among at risk populations.Objectives: The purpose of our study was to provide early influenza vaccine effectiveness (IVE) estimates for the ongoing influenza epidemic in France and compare these estimates over the six post-pandemic IVE.Study design: We used clinical and virological data collected in primary care by the French Sentinelles network. IVE in preventing influenza infection was estimated by the test-negative design method. The screening method was used to estimate IVE in preventing medically-attended influenza-like illness among target groups (<65 year with chronic diseases and ≥65 years) since 2010/11 influenza epidemic.Results: Early IVE estimates in primary care against influenza A(H3N2) were 48% (95% confidence interval (CI): 22 to 66) overall and 39% (95% CI: -17 to 69) among elderly (aged 65 and older). In comparison to the last six epidemics, 2016/17 early IVE in preventing influenza-like illness among target groups showed VE estimates higher to those reported during the 2011/12 and 2014/15 epidemics.Conclusions: The moderate 2016/17 IVE estimates were higher than those estimated during influenza A(H3N2) epidemics with vaccine mismatch.
|
Auteur(s) |
Cécile Souty
1
, Ana-Maria Vilcu
1
, Lisandru Capai
1, 2
, Sylvie van Der Werf
3, 4
, Martine Valette
5
, Thierry Blanchon
1
, Bruno Lina
5, 6
, Sylvie Behillil
3, 4
, Thomas Hanslik
1, 7, 8
, Alessandra Falchi
2
1
iPLESP -
Institut Pierre Louis d'Epidémiologie et de Santé Publique
( 267618 )
- 56, boulevard Vincent Auriol - CS 81393 - 75646 Paris Cedex 13
- France
2
EA Bioscope Corse Méditerranée : Dynamique des infections virales en milieu insulaire
( 432809 )
- Campus Grimaldi - 20250 Corte
- France
3
GMV-ARN (UMR_3569 / U-Pasteur_2) -
Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses
( 417138 )
- Département de Virologie, 25-28 rue du docteur Roux, 75724 Paris cedex 15
- France
4
CNR -
Centre National de Référence des virus influenzae (Grippe)
( 205198 )
- Unité Génétique moléculaire des virus à ARN
25-28, rue du Docteur Roux 75724 Paris Cedex 15
- France
5
Virpath -
Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control [CIRI]
( 543794 )
- Laboratoire de Virologie et Pathologies humaines – VirPath
Faculté de médecine RTH Laennec
Bâtiment B
7-11 rue Guillaume Paradin
69372 Lyon cedex 08
- France
6
CNR des virus influenza -
Laboratoire de Virologie [GH Nord HCL, Lyon]
( 555608 )
- France
7
Service de Médecine Interne
( 505691 )
- F-92100, Boulogne Billancourt, France
- France
8
UVSQ Santé -
Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
( 472222 )
- 2 avenue de la Source de la Bièvre - 78180 Montigny-le-Bretonneux
- France
|
Volume |
95
|
Page/Identifiant |
1 - 4
|
Date de publication |
2017-10
|
Langue du document |
Anglais
|
Date de production/écriture |
2017-02-22
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication électronique |
2017-08-09
|
Nom de la revue |
|
Domaine(s) |
|
Mots-clés |
en
influenza, influenza-like illness, primary care, vaccine effectiveness
|
DOI | 10.1016/j.jcv.2017.08.002 |
Origine :
Fichiers produits par l'(les) auteur(s)
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