Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
Fabrice Tranchida
(1)
,
Zo Rakotoniaina
(1)
,
Laetitia Shintu
(1)
,
Léopold Tchiakpe
(2)
,
Valérie Deyris
(1)
,
Mehdi Yemloul
(1)
,
Pierre Stocker
(3)
,
Nicolas Vidal
(3)
,
Odile Rimet
(2)
,
Abel Hiol
(4)
,
Stefano Caldarelli
(1)
Fabrice Tranchida
- Fonction : Auteur
- PersonId : 1002502
Laetitia Shintu
- Fonction : Auteur
- PersonId : 766228
- ORCID : 0000-0003-2730-121X
- IdRef : 113464479
Mehdi Yemloul
- Fonction : Auteur
- PersonId : 773269
- IdRef : 159499348
Résumé
The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in combination with multivariate analysis have been employed to characterize the NMR metabolite profiles and fatty acid composition of liver tissue respectively. The results showed a clear discrimination between HFS groups and controls involving metabolites such as glucose, glycogen, amino acids, acetate, choline, lysophosphatidylcholine, phosphatidylethanolamine, and β-hydroxybutyrate as well as an increase of MUFAs and a decrease of n-6 and n-3 PUFAs. Although the administration of CL did not counteract deleterious effects of the HFS diet, some metabolites, namely some n-6 PUFA and n-3 PUFA, and betaine were found to increase significantly in liver samples from rats having received extract of curcuma compared to those fed the HFS diet alone. This result suggests that curcuminoids may affect the transmethylation pathway and/or osmotic regulation. CL extract supplementation in rats appears to increase some of the natural defences preventing the development of fatty liver by acting on the choline metabolism to increase fat export from the liver.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
|
Résumé |
en
The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in combination with multivariate analysis have been employed to characterize the NMR metabolite profiles and fatty acid composition of liver tissue respectively. The results showed a clear discrimination between HFS groups and controls involving metabolites such as glucose, glycogen, amino acids, acetate, choline, lysophosphatidylcholine, phosphatidylethanolamine, and β-hydroxybutyrate as well as an increase of MUFAs and a decrease of n-6 and n-3 PUFAs. Although the administration of CL did not counteract deleterious effects of the HFS diet, some metabolites, namely some n-6 PUFA and n-3 PUFA, and betaine were found to increase significantly in liver samples from rats having received extract of curcuma compared to those fed the HFS diet alone. This result suggests that curcuminoids may affect the transmethylation pathway and/or osmotic regulation. CL extract supplementation in rats appears to increase some of the natural defences preventing the development of fatty liver by acting on the choline metabolism to increase fat export from the liver.
|
Auteur(s) |
Fabrice Tranchida
1
, Zo Rakotoniaina
1
, Laetitia Shintu
1
, Léopold Tchiakpe
2
, Valérie Deyris
1
, Mehdi Yemloul
1
, Pierre Stocker
3
, Nicolas Vidal
3
, Odile Rimet
2
, Abel Hiol
4
, Stefano Caldarelli
1
1
ISM2 -
Institut des Sciences Moléculaires de Marseille
( 186403 )
- Campus Saint Jérôme Av. escadrille Normandie Niemen
BP 531
13397 MARSEILLE CEDEX 20
- France
2
AMU PHARM -
Aix-Marseille Université - Faculté de pharmacie
( 416344 )
- 27 boulevard Jean Moulin - CS 30064 - 13285 Marseille cedex 5
- France
3
ICR -
Institut de Chimie Radicalaire
( 258556 )
- Avenue Escadrille Normandie-Niemen
Service D42
13397 Marseille cedex 20
- France
4
Qualisud Réunion -
Qualisud - Pôle de La Réunion
( 418883 )
- Faculté des Sciences et Technologies - Université de la Réunion, 2, rue Joseph Wetzell 97490 Sainte-Clotilde
- La Réunion
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2017
|
Date de publication électronique |
2017-07-19
|
Volume |
7
|
Page/Identifiant |
5880
|
Domaine(s) |
|
DOI | 10.1038/s41598-017-06220-0 |
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