Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
Denis Pierron
(1)
,
Margit Heiske
(1)
,
Harilanto Razafindrazaka
(1, 2)
,
Veronica Pereda-Loth
(1)
,
Jazmin Sanchez
(1)
,
Omar Alva
(1)
,
Amal Arachiche
(1)
,
Anne Boland
(3)
,
Robert Olaso
(3)
,
Jean-François Deleuze
(3)
,
Francois-Xavier Ricaut
(1)
,
Jean-Aimé Rakotoarisoa
(4)
,
Chantal Radimilahy
(4)
,
Mark Stoneking
(5)
,
Thierry Letellier
(1)
Harilanto Razafindrazaka
- Fonction : Auteur
- PersonId : 750256
- IdHAL : harilanto-razafindrazaka
- ORCID : 0000-0001-5209-4780
- IdRef : 161284108
Veronica Pereda-Loth
- Fonction : Auteur
- PersonId : 765275
- ORCID : 0000-0002-7365-6217
Anne Boland
- Fonction : Auteur
- PersonId : 757786
- ORCID : 0000-0001-8789-5676
Robert Olaso
- Fonction : Auteur
- PersonId : 774936
- ORCID : 0000-0001-7631-9657
Francois-Xavier Ricaut
- Fonction : Auteur
- PersonId : 181458
- IdHAL : francois-xavier-ricaut
- ORCID : 0000-0001-7609-7898
- IdRef : 139293590
Mark Stoneking
- Fonction : Auteur
- PersonId : 754815
- IdHAL : mark-stoneking
- ORCID : 0000-0001-9044-6679
Résumé
While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
|
Résumé |
en
While admixed populations offer a unique opportunity to detect selection, the admixture in most of the studied populations occurred too recently to produce conclusive signals. By contrast, Malagasy populations originate from admixture between Asian and African populations that occurred ~27 generations ago, providing power to detect selection. We analyze local ancestry across the genomes of 700 Malagasy and identify a strong signal of recent positive selection, with an estimated selection coefficient >0.2. The selection is for African ancestry and affects 25% of chromosome 1, including the Duffy blood group gene. The null allele at this gene provides resistance to Plasmodium vivax malaria, and previous studies have suggested positive selection for this allele in the Malagasy population. This selection event also influences numerous other genes implicated in immunity, cardiovascular diseases, and asthma and decreases the Asian ancestry genome-wide by 10%, illustrating the role played by selection in recent human history.
|
Auteur(s) |
Denis Pierron
1
, Margit Heiske
1
, Harilanto Razafindrazaka
1, 2
, Veronica Pereda-Loth
1
, Jazmin Sanchez
1
, Omar Alva
1
, Amal Arachiche
1
, Anne Boland
3
, Robert Olaso
3
, Jean-François Deleuze
3
, Francois-Xavier Ricaut
1
, Jean-Aimé Rakotoarisoa
4
, Chantal Radimilahy
4
, Mark Stoneking
5
, Thierry Letellier
1
1
AMIS -
Anthropologie Moléculaire et Imagerie de Synthèse
( 445683 )
- 37 Allées Jules Guesde
31073 Toulouse
- France
2
ADES -
Anthropologie bio-culturelle, Droit, Ethique et Santé
( 186857 )
- Faculté de Médecine Secteur Nord 51, Boulevard Pierre Dramard 13344 MARSEILLE CEDEX 15
- France
3
CNG -
Centre National de Génotypage
( 31446 )
- Centre National de Génotypage 2 rue Gaston Crémieux CP5721 91057 EVRY Cedex
- France
4
Université d'Antananarivo
( 300866 )
- BP 566 - Antananarivo 101 - Madagascar
- Madagascar
5
Max Planck Institute for Evolutionary Anthropology [Leipzig]
( 308156 )
- Deutscher Pl. 6, 04103 Leipzig
- Allemagne
|
Licence |
Paternité
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2018
|
Volume |
9
|
Numéro |
1
|
Page/Identifiant |
932
|
Domaine(s) |
|
Projet(s) ANR |
|
Mots-clés |
en
Population genetics, Malaria, Evolutionary genetics, Genome evolution
|
DOI | 10.1038/s41467-018-03342-5 |
Pubmed Id | 29500350 |
Origine :
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