Mosquito vector competence for dengue is modulated by insect-specific viruses
Roenick Proveti Olmo
(1, 2, 3)
,
Yaovi M. H. Todjro
(3)
,
Eric R. G. R. Aguiar
(3)
,
João Paulo P. de Almeida
(3)
,
Flávia V. Ferreira
(3)
,
Juliana N. Armache
(3)
,
Isaque J. S. de Faria
(3)
,
Alvaro G. A. Ferreira
,
Siad C. G. Amadou
(3)
,
Ana Teresa S. Silva
(3)
,
Kátia P. R. de Souza
(3)
,
Ana Paula P. Vilela
(3)
,
Antinéa Babarit
(2, 1)
,
Cheong H. Tan
(4)
,
Mawlouth Diallo
(5)
,
Alioune Gaye
(5)
,
Christophe Paupy
(6)
,
Judicaël Obame-Nkoghe
(7, 8)
,
Tessa M. Visser
(9)
,
Constantianus J. M. Koenraadt
(9)
,
Merril A. Wongsokarijo
,
Ana Luiza C. Cruz
,
Mariliza T. Prieto
,
Maisa C. P. Parra
,
Maurício L. Nogueira
(10)
,
Vivian Avelino-Silva
,
Renato N. Mota
,
Magno A. Z. Borges
,
Betânia P. Drumond
,
Erna G. Kroon
,
Mario Recker
(11)
,
Luigi Sedda
(12)
,
Eric Marois
(2, 1)
,
Jean-Luc Imler
(2, 1)
,
João T. Marques
(3)
1
RIDI - UPR 9002 -
Réponse immunitaire et developpement chez les insectes
2 M3I - Modèles Insectes de l'Immunité Innée
3 Universidade do Estado de Minas Gerais = Minas Gerais State University
4 NEA - National Environment Agency [Singapore]
5 Institut Pasteur de Dakar
6 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
7 USTM - Université des Sciences et Techniques de Masuku
8 CIRMF - Centre International de Recherches Médicales de Franceville
9 WUR - Wageningen University and Research [Wageningen]
10 University of Texas Medical Branch at Galveston
11 Universitätsklinikum Tübingen - University Hospital of Tübingen
12 Lancaster University
2 M3I - Modèles Insectes de l'Immunité Innée
3 Universidade do Estado de Minas Gerais = Minas Gerais State University
4 NEA - National Environment Agency [Singapore]
5 Institut Pasteur de Dakar
6 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
7 USTM - Université des Sciences et Techniques de Masuku
8 CIRMF - Centre International de Recherches Médicales de Franceville
9 WUR - Wageningen University and Research [Wageningen]
10 University of Texas Medical Branch at Galveston
11 Universitätsklinikum Tübingen - University Hospital of Tübingen
12 Lancaster University
Alvaro G. A. Ferreira
- Fonction : Auteur
Antinéa Babarit
- Fonction : Auteur
- PersonId : 1216224
Christophe Paupy
- Fonction : Auteur
- PersonId : 173628
- IdHAL : christophe-paupy
- ORCID : 0000-0002-7122-2079
- IdRef : 089287606
Merril A. Wongsokarijo
- Fonction : Auteur
Ana Luiza C. Cruz
- Fonction : Auteur
Mariliza T. Prieto
- Fonction : Auteur
Maisa C. P. Parra
- Fonction : Auteur
Vivian Avelino-Silva
- Fonction : Auteur
Renato N. Mota
- Fonction : Auteur
Magno A. Z. Borges
- Fonction : Auteur
Betânia P. Drumond
- Fonction : Auteur
Erna G. Kroon
- Fonction : Auteur
Eric Marois
- Fonction : Auteur
- PersonId : 926226
Jean-Luc Imler
- Fonction : Auteur
- PersonId : 1055641
Résumé
Aedes aegypti and A. albopictus mosquitoes are the main vectors for dengue virus (DENV) and other arboviruses, including Zika virus (ZIKV). Understanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public health and targeted interventions. Reasoning that interactions among viruses in the vector insect might affect transmission, we analysed the viromes of 815 urban Aedes mosquitoes collected from 12 countries worldwide. Two mosquito-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most abundant in A. aegypti worldwide. Spatiotemporal analyses of virus circulation in an endemic urban area revealed a 200% increase in chances of having DENV in wild A. aegypti mosquitoes when both HTV and PCLV were present. Using a mouse model in the laboratory, we showed that the presence of HTV and PCLV increased the ability of mosquitoes to transmit DENV and ZIKV to a vertebrate host. By transcriptomic analysis, we found that in DENV-infected mosquitoes, HTV and PCLV block the downregulation of histone H4, which we identify as an important proviral host factor in vivo.
Domaines
ImmunologieFormat du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Mosquito vector competence for dengue is modulated by insect-specific viruses
|
Résumé |
en
Aedes aegypti and A. albopictus mosquitoes are the main vectors for dengue virus (DENV) and other arboviruses, including Zika virus (ZIKV). Understanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public health and targeted interventions. Reasoning that interactions among viruses in the vector insect might affect transmission, we analysed the viromes of 815 urban Aedes mosquitoes collected from 12 countries worldwide. Two mosquito-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most abundant in A. aegypti worldwide. Spatiotemporal analyses of virus circulation in an endemic urban area revealed a 200% increase in chances of having DENV in wild A. aegypti mosquitoes when both HTV and PCLV were present. Using a mouse model in the laboratory, we showed that the presence of HTV and PCLV increased the ability of mosquitoes to transmit DENV and ZIKV to a vertebrate host. By transcriptomic analysis, we found that in DENV-infected mosquitoes, HTV and PCLV block the downregulation of histone H4, which we identify as an important proviral host factor in vivo.
|
Auteur(s) |
Roenick Proveti Olmo
1, 2, 3
, Yaovi M. H. Todjro
3
, Eric R. G. R. Aguiar
3
, João Paulo P. de Almeida
3
, Flávia V. Ferreira
3
, Juliana N. Armache
3
, Isaque J. S. de Faria
3
, Alvaro G. A. Ferreira
, Siad C. G. Amadou
3
, Ana Teresa S. Silva
3
, Kátia P. R. de Souza
3
, Ana Paula P. Vilela
3
, Antinéa Babarit
2, 1
, Cheong H. Tan
4
, Mawlouth Diallo
5
, Alioune Gaye
5
, Christophe Paupy
6
, Judicaël Obame-Nkoghe
7, 8
, Tessa M. Visser
9
, Constantianus J. M. Koenraadt
9
, Merril A. Wongsokarijo
, Ana Luiza C. Cruz
, Mariliza T. Prieto
, Maisa C. P. Parra
, Maurício L. Nogueira
10
, Vivian Avelino-Silva
, Renato N. Mota
, Magno A. Z. Borges
, Betânia P. Drumond
, Erna G. Kroon
, Mario Recker
11
, Luigi Sedda
12
, Eric Marois
2, 1
, Jean-Luc Imler
2, 1
, João T. Marques
3
1
RIDI - UPR 9002 -
Réponse immunitaire et developpement chez les insectes
( 81522 )
- Institut de biologie moléculaire et cellulaire 15, rue rené Descartes 67084 Strasbourg cedex
- France
2
M3I -
Modèles Insectes de l'Immunité Innée
( 561325 )
- 15 Rue René Descartes
67084 STRASBOURG CEDEX
- France
3
Universidade do Estado de Minas Gerais = Minas Gerais State University
( 1083143 )
- Cidade Administrativa Presidente Tancredo Neves
Rodovia Papa João Paulo II, 4143
Ed. Minas - 8º andar
Belo Horizonte - MG
- Brésil
4
NEA -
National Environment Agency [Singapore]
( 573712 )
- Singapour
5
Institut Pasteur de Dakar
( 42095 )
- B.P. 220 Dakar
- Sénégal
6
MIVEGEC -
Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
( 1100703 )
- 911 Avenue Agropolis BP 64501 34394 Montpellier cedex 5
- France
7
USTM -
Université des Sciences et Techniques de Masuku
( 377466 )
- Franceville
- Gabon
8
CIRMF -
Centre International de Recherches Médicales de Franceville
( 51216 )
- Franceville, Gabon
- Gabon
9
WUR -
Wageningen University and Research [Wageningen]
( 356395 )
- Droevendaalsesteeg 4, 6708 PB Wageningen
- Pays-Bas
10
University of Texas Medical Branch at Galveston
( 551097 )
- 301 University Boulevard
Galveston, TX 77555
- États-Unis
11
Universitätsklinikum Tübingen - University Hospital of Tübingen
( 259521 )
- Postfach 2669
72016 Tübingen
- Allemagne
12
Lancaster University
( 450363 )
- Bailrigg, Lancaster, LA1 4YW
- Royaume-Uni
|
Langue du document |
Anglais
|
Date de production/écriture |
2023
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2023-01-05
|
Volume |
8
|
Numéro |
1
|
Page/Identifiant |
135-149
|
Domaine(s) |
|
Projet(s) ANR |
|
DOI | 10.1038/s41564-022-01289-4 |
Base Horizon | fdi:010088453 |
Origine :
Fichiers produits par l'(les) auteur(s)
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