Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)

Valentina Sanchez Picot; Thomas Bénet; Melina Messaoudi; Jean-Noël Telles; Monidarin Chou; Tekchheng Eap; Jianwei Wang; Kunling Shen; Jean-William Pape; Vanessa Rouzier; Shally Awasthi; Nitin Pandey; Ashish Bavdekar; Sonali Sanghvi; Annick Robinson; Bénédicte Contamin; Jonathan Hoffmann; Maryam Sylla; Souleymane Diallo; Pagbajabyn Nymadawa; Budragchaagiin Dash-Yandag; Graciela Russomando; Wilma Basualdo; Marilda M. Siqueira; Patricia Barreto; Florence Komurian-Pradel; Guy Vernet; Hubert Endtz; Philippe Vanhems; Gláucia Paranhos-Baccalà

doi:10.1186/s12879-014-0635-8

Article dans une revue BMC Infectious Diseases Année : 2014

Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)

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Valentina Sanchez Picot

Fonction : Auteur

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Thomas Bénet

Fonction : Auteur
PersonId : 1038398

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Melina Messaoudi

Fonction : Auteur

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Jean-Noël Telles

Fonction : Auteur

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Monidarin Chou

Fonction : Auteur

University of Health Sciences [Phnom-Penh, Cambodia]

Tekchheng Eap

Fonction : Auteur

National Pediatric Hospital

Jianwei Wang

Fonction : Auteur

Institute of Pathogen Biology

Kunling Shen

Fonction : Auteur

Beijing Pediatric Research Institute

Jean-William Pape

Fonction : Auteur

GHESKIO Centers [Port-au-Prince]

Vanessa Rouzier

Fonction : Auteur

GHESKIO Centers [Port-au-Prince]

Shally Awasthi

Fonction : Auteur

Lucknow University

Nitin Pandey

Fonction : Auteur

Lucknow University

Ashish Bavdekar

Fonction : Auteur

KEM Hospital Research Center

Sonali Sanghvi

Fonction : Auteur

KEM Hospital Research Center

Annick Robinson

Fonction : Auteur

Centre Hospitalier Universitaire Mère-Enfant de Tsaralalàna

Bénédicte Contamin

Fonction : Auteur

Centre d’Infectiologie Charles-Mérieux, Université d’Antananarivo - Madagascar

Jonathan Hoffmann

Fonction : Auteur
PersonId : 1321486
ORCID : 0000-0002-2400-8862

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Maryam Sylla

Fonction : Auteur

Gabriel Toure Hospital [Bamako, Mali]

Souleymane Diallo

Fonction : Auteur
PersonId : 960864

Centre d'Infectiologie Charles Mérieux, Bamako, Mali

Pagbajabyn Nymadawa

Fonction : Auteur

Mongolian Academy of Sciences

Budragchaagiin Dash-Yandag

Fonction : Auteur

Bayanzurkh District General Hospital [Mongolia]

Graciela Russomando

Fonction : Auteur

Research Institut of Health

Wilma Basualdo

Fonction : Auteur

Universidad Nacional de Asunción [Paraguay] = National University of Asunción = Université nationale d'Asunción

Marilda M. Siqueira

Fonction : Auteur

Instituto Oswaldo Cruz = Oswaldo Cruz Institute [Rio de Janeiro]

Patricia Barreto

Fonction : Auteur

Instituto Oswaldo Cruz = Oswaldo Cruz Institute [Rio de Janeiro]

Florence Komurian-Pradel

Fonction : Auteur
PersonId : 1239940
ORCID : 0000-0002-1023-0796

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Guy Vernet

Fonction : Auteur

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Hubert Endtz

Fonction : Auteur

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Philippe Vanhems

Fonction : Auteur
PersonId : 759616
ORCID : 0000-0003-3188-1456
IdRef : 061621196

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Gláucia Paranhos-Baccalà

Fonction : Auteur
PersonId : 1239941
ORCID : 0000-0002-6369-5837

Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI]

Résumé

BACKGROUND: Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case-control study of 5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. METHODS/DESIGN: A multicenter case-control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children 5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. DISCUSSION: This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention.

Mots clés

Anti-Bacterial Agents Bacteria Brazil C-Reactive Protein Calcitonin Calcitonin Gene-Related Peptide Cambodia Case-Control Studies Child Preschool China Clinical Protocols Developing Countries Female Haiti Humans India Infant Madagascar Male Mali Mongolia Paraguay Pleural Effusion Pneumonia Protein Precursors Viruses

Domaines

Immunologie Bactériologie Virologie

Liste complète des métadonnées

Format du dépôt	Notice
Type de dépôt	Article dans une revue
Titre	en Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)
Résumé	en BACKGROUND: Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case-control study of 5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. METHODS/DESIGN: A multicenter case-control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children 5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. DISCUSSION: This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention.
Auteur(s)	Valentina Sanchez Picot ¹ , Thomas Bénet ¹ , Melina Messaoudi ¹ , Jean-Noël Telles ¹ , Monidarin Chou ² , Tekchheng Eap ³ , Jianwei Wang ⁴ , Kunling Shen ⁵ , Jean-William Pape ⁶ , Vanessa Rouzier ⁶ , Shally Awasthi ⁷ , Nitin Pandey ⁷ , Ashish Bavdekar ⁸ , Sonali Sanghvi ⁸ , Annick Robinson ⁹ , Bénédicte Contamin ¹⁰ , Jonathan Hoffmann ¹ , Maryam Sylla ¹¹ , Souleymane Diallo ¹² , Pagbajabyn Nymadawa ¹³ , Budragchaagiin Dash-Yandag ¹⁴ , Graciela Russomando ¹⁵ , Wilma Basualdo ¹⁶ , Marilda M. Siqueira ¹⁷ , Patricia Barreto ¹⁷ , Florence Komurian-Pradel ¹ , Guy Vernet ¹ , Hubert Endtz ¹ , Philippe Vanhems ¹ , Gláucia Paranhos-Baccalà ¹ 1 LPE-Fondation Mérieux - Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory [CIRI] ( 543793 ) - 21 Avenue Tony Garnier 69365 LYON Cedex 07 - France Centre International de Recherche en Infectiologie ( 222995 ) ; École normale supérieure de Lyon ( 6818 ) ; Université de Lyon ( 301088 ) ; Université Claude Bernard Lyon 1 ( 194495 ) ; Université de Lyon ( 301088 ) ; Université Jean Monnet - Saint-Étienne ( 300284 ) ; Institut National de la Santé et de la Recherche Médicale U1111 ( 303623 ) ; Centre National de la Recherche Scientifique UMR5308 ( 441569 ) 2 UHS - University of Health Sciences [Phnom-Penh, Cambodia] ( 559739 ) - 73 Preah Monivong Blvd (93), Phnom Penh, Cambodge - Cambodge 3 National Pediatric Hospital ( 414536 ) - 73 Preah Monivong Boulevard, Phnom Penh - Cambodge University of Health Sciences – Cambodia ( 414535 ) 4 Institute of Pathogen Biology ( 168885 ) - Beijing 100176, China - Chine China Academy of Chinese Medical Sciences ( 348277 ) 5 Beijing Pediatric Research Institute ( 358544 ) - - France 6 GHESKIO Centers [Port-au-Prince] ( 520217 ) - Port Au Prince - Haïti 7 Lucknow University ( 313178 ) - Lucknow 226 007,INDIA - Inde 8 KEM Hospital Research Center ( 577071 ) - Pune, India - Inde 9 CHUMET - Centre Hospitalier Universitaire Mère-Enfant de Tsaralalàna ( 546270 ) - rue Patrice Lumumba, Tsaralalàna, 101, Antananarivo, Madagascar. - Madagascar 10 Centre d’Infectiologie Charles-Mérieux, Université d’Antananarivo - Madagascar ( 527931 ) - Centre d’infectiologie Charles-Mérieux, Ankatso, Université d’Antananarivo, BP 4299, 101 Antananarivo, Madagascar - Madagascar Université d'Antananarivo ( 300866 ) 11 Gabriel Toure Hospital [Bamako, Mali] ( 545849 ) - Mali 12 Centre d'Infectiologie Charles Mérieux, Bamako, Mali ( 534056 ) - Mali 13 MAS - Mongolian Academy of Sciences ( 337004 ) - Amariin gudamj 1, Ulaanbaatar 210620, Mongolia - Mongolie 14 Bayanzurkh District General Hospital [Mongolia] ( 577218 ) - Ulaanbaatar - Mongolie 15 Research Institut of Health ( 577072 ) - Asuncion, Paraguay - Paraguay 16 UNA - Universidad Nacional de Asunción [Paraguay] = National University of Asunción = Université nationale d'Asunción ( 523037 ) - Campus de la UNA, Km 11 - San Lorenzo, Paraguay - Paraguay 17 IOC - Instituto Oswaldo Cruz = Oswaldo Cruz Institute [Rio de Janeiro] ( 520680 ) - Avenida Brasil 4.365 - Manguinhos, Rio de Janeiro, RJ - Brésil Fundação Oswaldo Cruz / Oswaldo Cruz Foundation ( 488707 ) ; Pasteur Network (Réseau International des Instituts Pasteur) ( 301247 )
Langue du document	Anglais
Nom de la revue	BMC Infect Dis - BMC Infectious Diseases (ISSN : 1471-2334) BioMed Central Publié par BioMed Central http://www.biomedcentral.com/bmcinfectdis/
Vulgarisation	Non
Comité de lecture	Oui
Audience	Internationale
Date de publication	2014-12
Volume	14
Page/Identifiant	635
Domaine(s)	Sciences du Vivant [q-bio]/Immunologie Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Mots-clés	en Anti-Bacterial Agents, Bacteria, Brazil, C-Reactive Protein, Calcitonin, Calcitonin Gene-Related Peptide, Cambodia, Case-Control Studies, Child, Preschool, China, Clinical Protocols, Developing Countries, Female, Haiti, Humans, India, Infant, Madagascar, Male, Mali, Mongolia, Paraguay, Pleural Effusion, Pneumonia, Protein Precursors, Viruses
DOI	10.1186/s12879-014-0635-8
Pubmed Id	25927410
PubMed Central	PMC4272811

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https://hal.science/hal-01911545

Soumis le : vendredi 2 novembre 2018 à 19:36:38

Dernière modification le : mardi 12 novembre 2024 à 15:20:07

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hal-01911545, version 1 (02-11-2018)

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HAL Id : hal-01911545 , version 1
DOI : 10.1186/s12879-014-0635-8
PUBMED : 25927410
PUBMEDCENTRAL : PMC4272811

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Valentina Sanchez Picot, Thomas Bénet, Melina Messaoudi, Jean-Noël Telles, Monidarin Chou, et al.. Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network). BMC Infectious Diseases, 2014, 14, pp.635. ⟨10.1186/s12879-014-0635-8⟩. ⟨hal-01911545⟩

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Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)

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