Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana–Brazil): Associated Factors and Spatial Distribution

To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l'Oyapock, located along the Brazilian border. The prevalence of Plasmodium spp. was determined using a rapid diagnostic test (RDT) and a polymerase chain reaction (PCR). Demographic, house locations, medical history, and biological data were analyzed. Factors associated with Plasmodium spp. carriage were analyzed using logistic regression, and the carriage localization was investigated through spatial cluster analysis. Of the 1,501 samples analyzed with PCR, positive results totaled 90 and 10 for Plasmodium vivax and Plasmodium falciparum, respectively. The general PCR prevalence was 6.6% [5.3-7.9], among which 74% were asymptomatic. Only 13/1,549 were positive by RDT. In multivariate analysis, participants older than 15 years, living in a remote neighborhood, with a prior history of malaria, anemia, and thrombocytopenia were associated with an increased odds of Plasmodium spp. carriage. High-risk clusters of P. vivax carriage were detected in the most remote neighborhoods on the village outskirts and two small foci in the village center. We also detected a hot spot for both P. vivax and P. falciparum symptomatic carriers in the northwestern part of the village. The present study confirms a wide-scale presence of asymptomatic P. falciparum and P. vivax carriers in this area. Although they were more often located in remote areas, their geographic distribution was spatially heterogeneous and complex.

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Santé publique et épidémiologie Maladies infectieuses Applications [stat.AP]

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Format du dépôt	Fichier
Type de dépôt	Article dans une revue
Résumé	en To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l'Oyapock, located along the Brazilian border. The prevalence of Plasmodium spp. was determined using a rapid diagnostic test (RDT) and a polymerase chain reaction (PCR). Demographic, house locations, medical history, and biological data were analyzed. Factors associated with Plasmodium spp. carriage were analyzed using logistic regression, and the carriage localization was investigated through spatial cluster analysis. Of the 1,501 samples analyzed with PCR, positive results totaled 90 and 10 for Plasmodium vivax and Plasmodium falciparum, respectively. The general PCR prevalence was 6.6% [5.3-7.9], among which 74% were asymptomatic. Only 13/1,549 were positive by RDT. In multivariate analysis, participants older than 15 years, living in a remote neighborhood, with a prior history of malaria, anemia, and thrombocytopenia were associated with an increased odds of Plasmodium spp. carriage. High-risk clusters of P. vivax carriage were detected in the most remote neighborhoods on the village outskirts and two small foci in the village center. We also detected a hot spot for both P. vivax and P. falciparum symptomatic carriers in the northwestern part of the village. The present study confirms a wide-scale presence of asymptomatic P. falciparum and P. vivax carriers in this area. Although they were more often located in remote areas, their geographic distribution was spatially heterogeneous and complex.
Titre	en Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana–Brazil): Associated Factors and Spatial Distribution
Auteur(s)	Emilie Mosnier ^{1, 2} , Emmanuel Roux ^{3, 4} , Claire Cropet ⁵ , Yassamine Lazrek ⁶ , Olivier Moriceau ⁶ , Mélanie Gaillet ¹ , Luana Mathieu ⁶ , Mathieu Nacher ⁵ , Magalie Pierre Demar ⁷ , Guillaume Odonne ⁸ , Maylis Douine ^{9, 2} , Céline Michaud ¹ , Stéphane Pelleau ⁶ , Félix Djossou ¹⁰ , Lise Musset ⁶ 1 Pôle des Centres Délocalisés de Prévention et de Soins [CH Andrée Rosemon, Guyane Française] ( 542554 ) - 97306 Cayenne. - Guyane française Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] ( 494314 ) 2 EPat - Ecosystemes Amazoniens et Pathologie Tropicale ( 441996 ) - Campus de Troubiran - BP 20792 - 97337 CAYENNE CEDEX - Guyane française Institut National de la Santé et de la Recherche Médicale ( 303623 ) ; Université de Guyane EA3593 ( 424370 ) 3 UMR 228 Espace-Dev, Espace pour le développement ( 196623 ) - IRD - Maison de la Télédétection - 500 rue Jean-François Breton - 34093 Montpellier - France Institut de Recherche pour le Développement ( 67872 ) ; Université de Perpignan Via Domitia ( 101475 ) ; Avignon Université ( 195507 ) ; Université de La Réunion ( 300316 ) ; Université de Montpellier ( 410122 ) ; Université de Guyane ( 424370 ) ; Université des Antilles ( 524399 ) 4 ICICT - Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro] ( 557248 ) - Av. Brasil, 4.365 - Pavilhão Haity Moussatché - Manguinhos, Rio de Janeiro - Brésil Fundação Oswaldo Cruz / Oswaldo Cruz Foundation ( 488707 ) ; Pasteur Network (Réseau International des Instituts Pasteur) ( 301247 ) 5 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane ( 171463 ) - Cayenne - Guyane française Institut National de la Santé et de la Recherche Médicale CIE802 ( 303623 ) ; CHU Pointe-à-Pitre / Abymes [Guadeloupe] ( 328176 ) ; Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] ( 494314 ) ; Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] ( 494317 ) 6 CNR - laboratoire associé - Centre National de Référence du Paludisme [Cayenne, Guyane française] ( 152475 ) - 23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex - Guyane française Institut Pasteur de la Guyane ( 300193 ) ; Pasteur Network (Réseau International des Instituts Pasteur) ( 301247 ) 7 Laboratoire Hospitalier et Universitaire Parasitologie Mycologie ( 267161 ) - BP 6006 - 97300 Cayenne - Guyane française Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] ( 494314 ) 8 LEEISA - Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens ( 456753 ) - Centre de recherche de Montabo IRD 275 route de Montabo BP 70 620 97 334 Cayenne Cedex Tel. (+594) 05 94 29 20 03 - Guyane française Institut Français de Recherche pour l'Exploitation de la Mer ( 300022 ) ; Université de Guyane ( 424370 ) ; Centre National de la Recherche Scientifique UAR3456 / USR3456 ( 441569 ) 9 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane ( 260794 ) - Unité de Maladies infectieuses, génétiques, et émergentes - Av des flamboyants 97306 Cayenne - France Université des Antilles et de la Guyane EA3593 ( 93016 ) ; Institut National de la Santé et de la Recherche Médicale CIC1424 ( 303623 ) ; CHU Pointe-à-Pitre / Abymes [Guadeloupe] ( 328176 ) ; CHU de Fort de France ( 360574 ) ; Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] ( 494314 ) 10 UMIT - Unité des Maladies Infectieuses et Tropicales ( 236174 ) - Av des flamboyants - B.P 6006 - Cayenne 97306 Cedex - Guyane française Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] ( 494314 )
Comité de lecture	Oui
Audience	Internationale
Date de publication	2020
Nom de la revue	Am J Trop Med Hyg - American Journal of Tropical Medicine and Hygiene (ISSN : 0002-9637) American Society of Tropical Medicine and Hygiene Publié par American Society of Tropical Medicine and Hygiene https://www.ajtmh.org/
Langue du document	Anglais
Numéro	1
Vulgarisation	Non
Page/Identifiant	130-141
Licence	Paternité
Date de publication électronique	2019-11-25
Volume	102
Financement	This study was funded by European Funds for Regional Development, N° Synergie: GY0012082, the Regional Agency for Health of French Guiana, Cayenne Hospital, the French Ministry for Research and Sante Publique France through the Institut Pasteur de la Guyane.
Collaboration/Projet	We are grateful to the study participants in STG, French Guiana; the NGO, DAAC, provided culturally adapted mediators, offering crucial support throughout this study; and Franck De Laval, Gaelle Walter, Bastien Bidaud, Loıc Epelboin, Alessia Melzani, and Mylene Cebe also contributed to data collection.
Domaine(s)	Sciences du Vivant [q-bio]/Santé publique et épidémiologie Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses Statistiques [stat]/Applications [stat.AP]
DOI	10.4269/ajtmh.19-0378
Base Horizon	fdi:010077752
Pubmed Id	31769403

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Prevalence_of_Plasmodium_spp_in_the_Amazonian_Border_context.pdf ( 1.17 Mo )

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https://hal.science/hal-02397337

Soumis le : lundi 9 décembre 2019 à 13:48:02

Dernière modification le : mardi 15 octobre 2024 à 15:10:22

Archivage à long terme le : mardi 10 mars 2020 à 20:09:20

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hal-02397337, version 1 (09-12-2019)

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Paternité - CC BY 4.0

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HAL Id : hal-02397337 , version 1
DOI : 10.4269/ajtmh.19-0378
IRD : fdi:010077752
PUBMED : 31769403

Citer

Emilie Mosnier, Emmanuel Roux, Claire Cropet, Yassamine Lazrek, Olivier Moriceau, et al.. Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana–Brazil): Associated Factors and Spatial Distribution. American Journal of Tropical Medicine and Hygiene, 2020, 102 (1), pp.130-141. ⟨10.4269/ajtmh.19-0378⟩. ⟨hal-02397337⟩

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