Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil
Emilie Mosnier
(1, 2)
,
Isabelle Dusfour
(3, 4)
,
Guillaume Lacour
(3, 5, 4)
,
Raphael Saldanha
(6)
,
Amandine Guidez
(3, 4)
,
Margarete Gomes
(7)
,
Alice Sanna
(8)
,
Yanouk Epelboin
(3)
,
Johana Restrepo
(9)
,
Damien Davy
(10)
,
Magalie Pierre Demar
(11, 12)
,
Félix Djossou
(1)
,
Maylis Douine
(12, 13)
,
Vanessa Ardillon
(14)
,
Mathieu Nacher
(13)
,
Lise Musset
(15, 3, 16, 17)
,
Emmanuel Roux
(18, 19, 6)
1
UMIT -
Unité des Maladies Infectieuses et Tropicales
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 Institut Pasteur de la Guyane
4 Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française]
5 Altopictus [Biarritz]
6 ICICT - Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro]
7 SVS-AP - Superintendência de Vigilância em Saúde do Amapá
8 Health Regional Agency [Cayenne]
9 CTG - Collectivité Territoriale de Guyane
10 LEEISA - Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens
11 Laboratoire Hospitalo-Universitaire de Parasitologie et Mycologie [Cayenne, Guyane Française]
12 UG - Université de Guyane
13 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane
14 Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE]
15 CNR - laboratoire associé - Centre National de Référence du Paludisme [Cayenne, Guyane française]
16 Laboratoire de Parasitologie [Cayenne, Guyane française]
17 CCOMS - Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française]
18 UMR 228 Espace-Dev, Espace pour le développement
19 LMI Sentinela [Rio de Janeiro]
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 Institut Pasteur de la Guyane
4 Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française]
5 Altopictus [Biarritz]
6 ICICT - Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro]
7 SVS-AP - Superintendência de Vigilância em Saúde do Amapá
8 Health Regional Agency [Cayenne]
9 CTG - Collectivité Territoriale de Guyane
10 LEEISA - Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens
11 Laboratoire Hospitalo-Universitaire de Parasitologie et Mycologie [Cayenne, Guyane Française]
12 UG - Université de Guyane
13 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane
14 Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE]
15 CNR - laboratoire associé - Centre National de Référence du Paludisme [Cayenne, Guyane française]
16 Laboratoire de Parasitologie [Cayenne, Guyane française]
17 CCOMS - Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française]
18 UMR 228 Espace-Dev, Espace pour le développement
19 LMI Sentinela [Rio de Janeiro]
Emilie Mosnier
- Function: Author
- PersonId: 996886
- IdHAL: emilie-mosnier
- ORCID: 0000-0002-6004-3323
Isabelle Dusfour
- Function: Author
- PersonId: 745756
- IdHAL: isabelle-dusfour
- ORCID: 0000-0002-5265-8432
- IdRef: 087295881
Guillaume Lacour
- Function: Author
- PersonId: 972685
Yanouk Epelboin
- Function: Author
- PersonId: 781437
- ORCID: 0000-0001-5192-7461
Damien Davy
- Function: Author
- PersonId: 974685
Maylis Douine
- Function: Author
- PersonId: 772327
- ORCID: 0000-0003-4616-6690
- IdRef: 134571533
Mathieu Nacher
- Function: Author
- PersonId: 11286
- IdHAL: mathieu-nacher
- ORCID: 0000-0001-9397-3204
- IdRef: 087955512
Lise Musset
- Function: Author
- PersonId: 734732
- IdHAL: lise-musset
- ORCID: 0000-0003-0215-4110
- IdRef: 060117362
Emmanuel Roux
- Function: Author
- PersonId: 9474
- IdHAL: emmanuel-roux-ird
- ORCID: 0000-0003-2266-8207
- IdRef: 069144753
Abstract
Background: In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017.
Methods: Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were estimated using French and Brazilian surveillance systems.
Results: On the French Guianese side of the border in Saint-Georges de l'Oyapock, the attack rate was 5.5% (n = 4000), reaching 51.4% (n = 175) in one Indigenous neighborhood. Entomological findings suggest a peak of Anopheles darlingi density in August and September. Two female An. darlingi (n = 1104, 0.18%) were found to be Pv-positive during this peak. During the same period, aggregated data from passive surveillance conducted by Brazilian and French Guianese border health centers identified 1566 cases of Pv infection. Temporal distribution during the 2007-2018 period displayed seasonal patterns with a peak in November 2017. Four clusters were identified among epidemic profiles of cross-border area localities. All localities of the first two clusters were Brazilian. The localization of the first cluster suggests an onset of the outbreak in an Indigenous reservation, subsequently expanding to French Indigenous neighborhoods and non-Native communities.
Conclusions: The current findings demonstrate a potential increase in malaria cases in an area with otherwise declining numbers. This is a transborder region where human mobility and remote populations challenge malaria control programs. This investigation illustrates the importance of international border surveillance and collaboration for malaria control, particularly in Indigenous villages and mobile populations.
Submission Type | File |
---|---|
Deposit type | Journal articles |
Abstract |
en
Background: In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017.
Methods: Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were estimated using French and Brazilian surveillance systems.
Results: On the French Guianese side of the border in Saint-Georges de l'Oyapock, the attack rate was 5.5% (n = 4000), reaching 51.4% (n = 175) in one Indigenous neighborhood. Entomological findings suggest a peak of Anopheles darlingi density in August and September. Two female An. darlingi (n = 1104, 0.18%) were found to be Pv-positive during this peak. During the same period, aggregated data from passive surveillance conducted by Brazilian and French Guianese border health centers identified 1566 cases of Pv infection. Temporal distribution during the 2007-2018 period displayed seasonal patterns with a peak in November 2017. Four clusters were identified among epidemic profiles of cross-border area localities. All localities of the first two clusters were Brazilian. The localization of the first cluster suggests an onset of the outbreak in an Indigenous reservation, subsequently expanding to French Indigenous neighborhoods and non-Native communities.
Conclusions: The current findings demonstrate a potential increase in malaria cases in an area with otherwise declining numbers. This is a transborder region where human mobility and remote populations challenge malaria control programs. This investigation illustrates the importance of international border surveillance and collaboration for malaria control, particularly in Indigenous villages and mobile populations.
|
Title |
en
Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil
|
Authors |
Emilie Mosnier
1, 2
, Isabelle Dusfour
3, 4
, Guillaume Lacour
3, 5, 4
, Raphael Saldanha
6
, Amandine Guidez
3, 4
, Margarete Gomes
7
, Alice Sanna
8
, Yanouk Epelboin
3
, Johana Restrepo
9
, Damien Davy
10
, Magalie Pierre Demar
11, 12
, Félix Djossou
1
, Maylis Douine
12, 13
, Vanessa Ardillon
14
, Mathieu Nacher
13
, Lise Musset
15, 3, 16, 17
, Emmanuel Roux
18, 19, 6
1
UMIT -
Unité des Maladies Infectieuses et Tropicales
( 236174 )
- Av des flamboyants - B.P 6006 - Cayenne 97306 Cedex
- French Guiana
2
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 541536 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 05.
- France
3
Institut Pasteur de la Guyane
( 300193 )
- 23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex
- French Guiana
4
Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française]
( 1053361 )
- 23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex
- French Guiana
5
Altopictus [Biarritz]
( 1060368 )
- France
6
ICICT -
Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro]
( 557248 )
- Av. Brasil, 4.365 - Pavilhão Haity Moussatché - Manguinhos, Rio de Janeiro
- Brazil
7
SVS-AP -
Superintendência de Vigilância em Saúde do Amapá
( 1040059 )
- Brazil
8
Health Regional Agency [Cayenne]
( 487522 )
- French Guiana
9
CTG -
Collectivité Territoriale de Guyane
( 572077 )
- 4179 Route de Montabo, Cayenne, Guyane française
- France
10
LEEISA -
Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens
( 456753 )
- Centre de recherche de Montabo IRD 275 route de Montabo
BP 70 620 97 334 Cayenne Cedex
Tel. (+594) 05 94 29 20 03
- French Guiana
11
Laboratoire Hospitalo-Universitaire de Parasitologie et Mycologie [Cayenne, Guyane Française]
( 545633 )
- French Guiana
12
UG -
Université de Guyane
( 424370 )
- Campus de Troubiran - BP 20792- 97337 Cayenne Cedex - Guyane
- French Guiana
13
CIC - Antilles Guyane -
Centre d'investigation clinique Antilles-Guyane
( 171463 )
- Cayenne
- French Guiana
14
Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE]
( 301893 )
-
- France
15
CNR - laboratoire associé -
Centre National de Référence du Paludisme [Cayenne, Guyane française]
( 152475 )
- 23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex
- French Guiana
16
Laboratoire de Parasitologie [Cayenne, Guyane française]
( 441988 )
- 23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex
- French Guiana
17
CCOMS -
Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française]
( 1071661 )
- 23 Avenue Pasteur BP 6010
97306 Cayenne Cedex
- French Guiana
18
UMR 228 Espace-Dev, Espace pour le développement
( 196623 )
- IRD - Maison de la Télédétection - 500 rue Jean-François Breton - 34093 Montpellier
- France
19
LMI Sentinela [Rio de Janeiro]
( 1006527 )
- Rio de Janeiro
- Brazil
|
Publication date |
2020-05-26
|
Fulltext language |
English
|
Journal |
|
Science popularization |
No
|
Peer-reviewed |
Yes
|
Audience |
International
|
Volume |
20
|
Page number |
373
|
Domain |
|
Keywords |
en
Amazonia, Anopheles darlingi, Brazil, French Guiana, Indigenous south Americans, Malaria, Outbreak investigation, Plasmodium vivax, Transnational.
|
DOI | 10.1186/s12879-020-05086-4 |
PubMed | 32456698 |
PubMed Central | PMC7249302 |
Origin :
Publisher files allowed on an open archive
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