Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders
Laetitia Dore
(1)
,
Erwann Durand
(2, 3)
,
Béatrice Bonafos
(1)
,
Jatuporn Chaiyut
(4)
,
Laurent Vaysse
(5)
,
Siriluck Liengprayoon
(4)
,
Sylvie Gaillet
(1)
,
Laurence Pessemesse
(1)
,
Karen Lambert
(6, 7)
,
Christelle Bertrand-Gaday
(1)
,
Charles Coudray
(1)
,
Ariane Sultan
(6)
,
François Casas
(1)
,
Christine Feillet-Coudray
(1)
1
DMEM -
Dynamique Musculaire et Métabolisme
2 UMR QualiSud - Démarche intégrée pour l'obtention d'aliments de qualité
3 Cirad-PERSYST - Département Performances des systèmes de production et de transformation tropicaux
4 KU - Kasetsart University [Bangkok, Thailand]
5 UPR BioWooEB - BioWooEB
6 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
7 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 UMR QualiSud - Démarche intégrée pour l'obtention d'aliments de qualité
3 Cirad-PERSYST - Département Performances des systèmes de production et de transformation tropicaux
4 KU - Kasetsart University [Bangkok, Thailand]
5 UPR BioWooEB - BioWooEB
6 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
7 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
Erwann Durand
- Fonction : Auteur
- PersonId : 773315
- ORCID : 0000-0002-0306-8081
- IdRef : 177207914
Jatuporn Chaiyut
- Fonction : Auteur
- PersonId : 1258641
- ORCID : 0000-0002-2286-8746
Siriluck Liengprayoon
- Fonction : Auteur
- PersonId : 1258642
- ORCID : 0000-0001-8309-6981
Sylvie Gaillet
- Fonction : Auteur
- PersonId : 1205628
- ORCID : 0000-0002-6050-0870
- IdRef : 174772033
Karen Lambert
- Fonction : Auteur
- PersonId : 19248
- IdHAL : karen-lambert
- ORCID : 0000-0002-6389-2451
- IdRef : 074194631
Christelle Bertrand-Gaday
- Fonction : Auteur
- PersonId : 742734
- IdHAL : christelle-bertrand-gaday
- ORCID : 0000-0003-0461-2402
- IdRef : 253120497
Charles Coudray
- Fonction : Auteur
- PersonId : 1207247
- ORCID : 0000-0003-2680-7796
- IdRef : 177133325
François Casas
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 754814
- IdHAL : francois-casas
- ORCID : 0000-0002-5535-8195
Connectez-vous pour contacter l'auteur
Christine Feillet-Coudray
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 736929
- IdHAL : christine-feillet-coudray
- ORCID : 0000-0001-8420-2811
- IdRef : 174771657
Connectez-vous pour contacter l'auteur
Résumé
The increase in obesity has become a major global health problem and is associated with numerous metabolic dysfunctions. Furan fatty acids (FuFAs) are minor lipids present in our diet. Recently we showed that FuFA-F2 extracted from Hevea brasiliensis latex stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. While skeletal muscle is essential for energy metabolism and is the predominant site of insulin-mediated glucose uptake in the post prandial state, our results suggested that FuFA-F2 could have favorable effects against obesity. The aim of this work was therefore to study whether a preventive nutritional supplementation with FuFA-F2 (40 mg or 110 mg/day/kg of body weight) in a diet-induced obesity (DIO) mouse model may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. We showed that 12 weeks of FuFA-F2 supplementation in DIO mice decreased fat mass, increased lean mass and restored normal energy expenditure. In addition, we found that FuFA-F2 improved insulin sensitivity. We revealed that FuFA-F2 increased muscle mass but had no effect on mitochondrial function and oxidative stress in skeletal muscle. Furthermore, we observed that FuFA-F2 supplementation reduced liver steatosis without impact on mitochondrial function and oxidative stress in liver. Our findings demonstrated for the first time that a preventive nutritional supplementation with a furan fatty acid in DIO mice reduced metabolic disorders and was able to mimic partly the positive effects of physical activity. This study highlights that nutritional FuFA-F2 supplementation could be an effective approach to treat obesity and metabolic syndrome.
Domaines
Sciences du Vivant [q-bio]Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders
|
Résumé |
en
The increase in obesity has become a major global health problem and is associated with numerous metabolic dysfunctions. Furan fatty acids (FuFAs) are minor lipids present in our diet. Recently we showed that FuFA-F2 extracted from Hevea brasiliensis latex stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. While skeletal muscle is essential for energy metabolism and is the predominant site of insulin-mediated glucose uptake in the post prandial state, our results suggested that FuFA-F2 could have favorable effects against obesity. The aim of this work was therefore to study whether a preventive nutritional supplementation with FuFA-F2 (40 mg or 110 mg/day/kg of body weight) in a diet-induced obesity (DIO) mouse model may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. We showed that 12 weeks of FuFA-F2 supplementation in DIO mice decreased fat mass, increased lean mass and restored normal energy expenditure. In addition, we found that FuFA-F2 improved insulin sensitivity. We revealed that FuFA-F2 increased muscle mass but had no effect on mitochondrial function and oxidative stress in skeletal muscle. Furthermore, we observed that FuFA-F2 supplementation reduced liver steatosis without impact on mitochondrial function and oxidative stress in liver. Our findings demonstrated for the first time that a preventive nutritional supplementation with a furan fatty acid in DIO mice reduced metabolic disorders and was able to mimic partly the positive effects of physical activity. This study highlights that nutritional FuFA-F2 supplementation could be an effective approach to treat obesity and metabolic syndrome.
|
Auteur(s) |
Laetitia Dore
1
, Erwann Durand
2, 3
, Béatrice Bonafos
1
, Jatuporn Chaiyut
4
, Laurent Vaysse
5
, Siriluck Liengprayoon
4
, Sylvie Gaillet
1
, Laurence Pessemesse
1
, Karen Lambert
6, 7
, Christelle Bertrand-Gaday
1
, Charles Coudray
1
, Ariane Sultan
6
, François Casas
1
, Christine Feillet-Coudray
1
1
DMEM -
Dynamique Musculaire et Métabolisme
( 1100780 )
- INRA 2 place Viala 34060 Montpellier Cedex 1
- France
2
UMR QualiSud -
Démarche intégrée pour l'obtention d'aliments de qualité
( 1100833 )
- 73 rue Jean-François Breton
34398 Montpellier Cedex 5, France
- France
3
Cirad-PERSYST -
Département Performances des systèmes de production et de transformation tropicaux
( 94474 )
- Avenue Agropolis TA B-DIR / 09 34398 Montpellier Cedex 5 France
- France
4
KU -
Kasetsart University [Bangkok, Thailand]
( 303549 )
- 50 Ngam Wong Wan Rd, Lat Yao Chatuchak Bangkok
- Thaïlande
5
UPR BioWooEB -
BioWooEB
( 418702 )
- TA B-114/16 73 Rue Jean-François Breton 34398 Montpellier Cedex 5, France
- France
6
PhyMedExp -
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
( 1100749 )
- 371 Avenue du Doyen G. Giraud, CHU Arnaud de Villeneuve, Bâtiment INSERM Crastes de Paulet - 34295 Montpellier Cedex 5
- France
7
CHRU Montpellier -
Centre Hospitalier Régional Universitaire [Montpellier]
( 258773 )
- 191 avenue du doyen Gaston Giraud 34295 Montpellier
- France
|
Nom de la revue |
|
Date de publication |
2023-08
|
Volume |
164
|
Page/Identifiant |
114945
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Public visé |
Scientifique
|
Version du document |
postprint
|
Licence |
Paternité
|
Langue du document |
Anglais
|
Domaine(s) |
|
Financement |
|
Mots-clés |
en
Furan fatty acids, Obesity, Insulin sensitivity, Skeletal muscle, Liver, Mitochondria
|
DOI | 10.1016/j.biopha.2023.114945 |
Pubmed Id | 37263166 |
UT key WOS | 001012613400001 |
Origine :
Fichiers produits par l'(les) auteur(s)
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